Biological Age

Biological age is a measure of an individual's physiological state, reflecting the 'wear and tear' of their body at a molecular level, distinct from their chronological age. It aims to quantify the body's 'wear and tear', offering insights into biological ageing and predicting mortality.

Biological age tests use computational models, known as biological ageing clocks, to estimate an individual's biological age by analysing biomarkers such as DNA methylation and plasma proteins.

Epigenetic biomarkers focus on changes in gene activity, influenced by lifestyle and environmental factors. The gut microbiome is another key area of biomarker research, as its composition changes with age and reflects environmental exposures.

Biological age tests are available as at-home diagnostic kits or in clinical settings, using saliva or blood samples. These clocks have applications in gerontology and geroscience, aiding in the development of anti-ageing interventions and studying the effects of lifestyle choices on ageing.

Age deceleration interventions, targeting diet, exercise, and stress management, aim to slow or reverse biological ageing as measured by these clocks.

Despite their potential, biological age tests present challenges related to individual variability, validation, and standardisation, due to complex biological and environmental interactions. The commercial availability of these tests has raised concerns about accuracy, reproducibility, and profit motives.

Biological age testing offers a promising tool for understanding ageing and developing interventions. However, further research is needed to address challenges and ensure reliable, standardised measurements. As the field evolves, biological age testing may become an essential component of personalised medicine, empowering individuals to make informed lifestyle choices and improve their healthspan.