Cdkn2a Positive Cells

Introduction

Cdkn2a positive cells are senescent cells that have been rejuvenated through targeted partial reprogramming. This process involves the delivery of Oct4, Sox2, and Klf4 (OSK) via an adeno-associated virus (AAV).

Rejuvenation Process

The rejuvenation process involves delivering OSK to Cdkn2a-positive cells, which reprograms them while maintaining their cellular identity. This process has been shown to improve lifespan, reduce inflammation, restore tissue integrity, and enhance wound healing in mouse models.

Applications

The rejuvenation of Cdkn2a positive cells has potential applications in treating age-associated disorders and improving overall health in aging individuals. The process has been shown to be a safer alternative to systemic senolytic therapies.

Mechanisms

The mechanisms underlying the rejuvenation of Cdkn2a positive cells involve the expression of nuclear reprogramming factors, which combat age-related deterioration at the cellular, tissue, and organismal levels. This process involves chromatin remodeling and molecular dynamics that underlie rejuvenation.

Conclusion

Cdkn2a positive cells are a promising area of research in the field of aging and age-related disorders. The rejuvenation of these cells through targeted partial reprogramming has the potential to improve health and treat age-associated disorders, offering a safer alternative to systemic senolytic therapies.