Epigenetic Reprogramming Reversal

Epigenetic reprogramming reversal is a therapeutic strategy aimed at slowing or reversing the biological ageing process. It involves targeting specific mechanisms and employing interventions to influence the pace of ageing, ultimately improving healthspan and reducing age-related diseases.

Cellular Reprogramming

Cellular reprogramming has emerged as a promising strategy for the amelioration of age-associated cellular phenotypes. In-vivo reprogramming approaches, however, have been limited by a lack of specificity and oncogenic risk. Recent breakthroughs have addressed these limitations, constituting a significant progression toward the development of safe and effective therapeutics for age-related pathologies.

Epigenetic Age Deceleration

Epigenetic age deceleration is a therapeutic goal aimed at slowing or reversing the biological ageing process. It involves targeting specific mechanisms and employing interventions to influence the pace of ageing, ultimately improving healthspan and reducing age-related diseases.

Chemical Cell Rejuvenation

Chemical cell rejuvenation is a promising approach to reversing the effects of cellular ageing and delaying the onset of age-related diseases. This strategy involves the use of chemical compounds to reprogramme cells, shifting them to a younger state.

Yamanaka Reprogramming Factors

Yamanaka reprogramming factors, named after Nobel Prize-winning biologist Shinya Yamanaka, are a set of transcription factors that can reprogramme adult cells into pluripotent stem cells. These factors, typically delivered via adeno-associated viruses, have shown potential in reversing age-related changes and improving cellular function.

Applications and Future Directions

The potential applications of chemical cell rejuvenation are vast, with the possibility of adapting these approaches for in vivo age reversal and the treatment of age-related diseases. However, further research is needed to fully understand the characteristics and mechanisms of partial chemical reprogramming. The development of novel techniques, such as maturation phase transient reprogramming (MPTR), offers a promising avenue for rejuvenating cells without the need for full reprogramming.