DNAm Aging Biomarkers

DNAm aging biomarkers are biological indicators that detect, monitor, and predict biological aging. These biomarkers are based on DNA methylation and offer insights into the impact of lifestyle and environmental factors on genetics and health.

Epigenetic Clocks

Epigenetic clocks are computational models that estimate an individual's biological age by analysing biomarkers such as DNA methylation and plasma proteins. These clocks include the Horvath, Hannum, Levine, GrimAge, and DunedinPACE clocks, each employing different biological measurements.

Applications

DNAm aging biomarkers have applications in gerontology and geroscience, aiding in the development of anti-aging interventions and studying the effects of lifestyle choices on aging. Age deceleration interventions, targeting diet, exercise, and stress management, aim to slow or reverse biological aging as measured by these clocks.

Challenges

Despite their potential, biological age tests present challenges related to individual variability, validation, and standardization, due to complex biological and environmental interactions. The commercial availability of these tests has raised concerns about accuracy, reproducibility, and profit motives.

Future Directions

Research into exposome aging is advancing our understanding of the intricate interplay between the microbiome, host biology, and environmental factors. This offers potential pathways for precision medicine and healthy aging. The development of more accurate and robust aging clocks, along with interventions targeting specific hallmarks of aging, holds promise for improving healthspan and mitigating age-related diseases.