Horvath Epigenetic Clock
The Horvath Epigenetic Clock is a biomarker that measures biological age based on DNA methylation patterns. It is a type of epigenetic clock that predicts chronological age accurately.
How it Works
The Horvath Epigenetic Clock analyses DNA methylation patterns of over 2,000 loci on the human genome to generate epigenetic age predictions. DNA methylation is an epigenetic phenomenon where chemical modifications occur on DNA that can influence gene expression. These modifications are strongly influenced by the environment and change over the course of a person's life.
Applications
The Horvath Epigenetic Clock has various applications in gerontology and geroscience, including:
- Developing anti-aging interventions: By monitoring the impact of interventions on the Horvath Epigenetic Clock, researchers can develop effective anti-aging strategies.
- Studying the effects of lifestyle choices on aging: The Horvath Epigenetic Clock can help researchers understand how lifestyle factors like diet, exercise, and stress management influence the aging process.
- Validating claims of exceptional longevity: The Horvath Epigenetic Clock can be used to verify age claims of centenarians and study the genetics of exceptional longevity.
Products and Services
The myDNAge® Test is a commercial product based on the Horvath Epigenetic Clock. It is an epigenetic age determination test that analyses DNA methylation patterns to predict biological age. The test uses proprietary SWARM™ technology to analyse over 2,000 loci on the human genome and generate epigenetic age predictions.
Limitations and Future Directions
The Horvath Epigenetic Clock faces challenges related to individual variability, validation, and standardization. Future research should focus on:
- Improving accuracy and reliability: Through robust validation processes, researchers can enhance the accuracy and reliability of the Horvath Epigenetic Clock.
- Integrating multi-omic data: By combining data from multiple sources, researchers can enhance their understanding of the aging process and develop more effective interventions.
- Leveraging artificial intelligence: Advancements in AI can help analyse large datasets and identify patterns associated with aging.
By addressing these challenges and advancing our understanding of the Horvath Epigenetic Clock, researchers can develop more effective strategies for promoting healthy aging and preventing age-related diseases.